Neoadenoloside A, a highly functionalized diterpene C-glycoside, from Isodon adenolomus.
نویسندگان
چکیده
Neoadenoloside A (1), an unprecedented diterpene C-glycoside with a unique C(26) framework, along with lasiokaurin (3) were isolated from the leaves of Isodon adenolomus. The absolute configuration of 2, a derivative of 1, was determined by spectroscopic methods and single-crystal X-ray diffraction analysis.
منابع مشابه
Total synthesis of the Isodon diterpene sculponeatin N.
The total synthesis of sculponeatin N, a bioactive polycyclic diterpene isolated from Isodon sculponeatus, is reported. Key features of the synthesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficient formation of the bicyclo[3.2.1]octane ring system by a reductive radical cyclization.
متن کاملA Novel Diterpene Glycoside with Nine Glucose Units from Stevia rebaudiana Bertoni
Following our interest in new diterpene glycosides with better taste profiles than that of Rebaudioside M, we have recently isolated and characterized Rebaudioside IX-a novel steviol glycoside-from a commercially-supplied extract of Stevia rebaudiana Bertoni. This molecule contains a hexasaccharide group attached at C-13 of the central diterpene core, and contains three additional glucose units...
متن کاملIridoid and Furanolabdane -Type Diterpene Glycosides from Rhizomes of Eremostachys azerbaijanica Rech. f.
Background and objectives: The rhizomes of Eremostachys azerbaijanica Rech. f.,as an indigenous plant in East Azerbaijan province of Iran, were studied for isolation and identification of possible phytoconstituents. Methods: The air- dried and ground rhizomes were extracted with n-hexane, dichloromethane (DCM) and methanol (MeOH) using a Soxhlet appara...
متن کاملBiosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
Plants produce an immense diversity of natural products (i.e. secondary or specialized metabolites) that offer a rich source of known and potentially new pharmaceuticals and other desirable bioproducts. The Traditional Chinese Medicinal plant Isodon rubescens (Lamiaceae) contains an array of bioactive labdane-related diterpenoid natural products. Of these, the ent-kauranoid oridonin is the most...
متن کاملPonicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis
Ponicidin is a diterpenoid extracted from the Chinese herb Isodon adenolomus, which has been reported as a therapeutic cytotoxic drug that may be used to treat various types of human cancer. The present study aimed to determine the antitumor effects of ponicidin, and to investigate its underlying mechanisms in colorectal cancer. The HT29 colorectal cancer cell line was used to detect the cytoto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 48 62 شماره
صفحات -
تاریخ انتشار 2012